Melatonin (N-acetyl-5-methoxytryptamine) is a hormone secreted by the pineal gland, also known as epiphysis cerebri, which is located at the base of the brain. Melatonin secretion follows the circadian rhythm: it starts in the evening, peaks during the night, decreases in the morning, and remains very low during the day.
The amount of melatonin produced, except for individual differences, depends largely on age: children produce significantly more melatonin than adults, while the amount of hormone secreted decreases with age.
Most evidence for the use of melatonin goes toward alleviating subjective feelings of jet lag, i.e. a sleep disorder caused by the rapid change of time zones during air travel.
Melatonin is widely available in the form of tablets, capsules, and even pastilles that dissolve under the tongue. When administered at an adequate dose of 1 mg before going to bed, melatonin contributes to reducing the time required for falling asleep.
Melatonin-rich foods include cherries and sour cherries, walnuts, corn, oatmeal, tomatoes, and ginger. Moreover, tryptophan is an essential amino acid that converts to melatonin in complex biochemical reactions. Natural sources of tryptophan include grains such as barley, oats and rice, pumpkin seeds, almonds, tomatoes, and some dairy products such as kefir and milk.
Melatonin use also entails the risk of developing side effects such as headache, drowsiness during the day, dizziness, stomach cramps, and a decreased libido. In addition, pregnant women, breastfeeding women, and children should not take dietary supplements with melatonin, while persons taking blood pressure or diabetes medication should consult with their doctor before use.
Andrea Volarić, MPharm / Senior Pharmacovigilance Associate
Lašćinska cesta 40
Planinska ulica 13/2
Office: +385 1 5588 297
Pharmacovigilance: +385 1 5588 297
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Full company name
Short company name
Marti Farm Ltd. Trade and Services
Marti Farm Ltd.
Lašćinska cesta 40, HR-10000 Zagreb
Planinska ulica 13/2, HR-10000 Zagreb
a limited liability company
Commercial Court of Zagreb
HRK 20,000.00 (paid in its entirety)
Martina Diminić Smetiško, director of the
company (Representing the company
individually and independently, Responsible
person for data protection)
HR3623600001102197724 (Zagrebačka banka)
HR4324020061100628669 (Erste banka)
Full company name: Marti Farm Ltd. Trade and Services
Short company name: Marti Farm Ltd.
Headquarters: Lašćinska cesta 40, HR-10000 Zagreb
Office: Planinska ulica 13/2, HR-10000 Zagreb
Legal form: a limited liability company
Court register: Commercial Court of Zagreb
Registration number: 080751121
Share capital: HRK 20,000.00 (paid in its entirety)
Authorized representative: Martina Diminić Smetiško, director of the company (Representing the company individually and independently, Responsible person for data protection)
Bank account: HR3623600001102197724 (Zagrebačka banka), HR4324020061100628669 (Erste banka)